The CDIATM C-reactive Protein Immunofluorescence Test Cassette is designed for quantitative determination of C-reactive protein in human serum, whole blood or plasma.
The test uses an anti-human CRP monoclonal antibody conjugated with fluorescence latex and another anti-human CRP monoclonal antibody coated on the test line. After the sample has been applied to the test strip, the fluorescence latex-labelled anti-human CRP monoclonal antibody binds with the CRP in sample and forms a marked antigen-antibody complex. This complex moves to the test card detection zone by capillary action. Then marked antigen-antibody complex is captured on the test line by the anti-human CRP monoclonal antibody. The fluorescence intensity of the test line increases in proportion to the amount of CRP in sample. Then insert test card into the Fluorescent Immunoassay Analyzer FIA7100, the concentration of CRP in sample will be determined and displayed on the screen.
CRP is a protein produced in response to inflammation and excessive deposits of cholesterol and fats in the liver and other tissues. The hs-CRP test accurately measures low levels of C-reactive protein to identify low but persistent levels of inflammation and thus helps predict a person's risk of developing CVD, heart attacks, and strokes. hs-CRP levels indicate an increased propensity for plaque disruption and/ or thrombosis. Levels of hs-CRP greater than 3 mg/l predict recurrent coronary events, thrombotic complications after angioplasty, poor outcome in the setting of unstable angina, and vascular complications after bypass surgery (CABG). It is also useful in determining whether or not more intensive treatment is warranted and in monitoring how well a patient is responding to lifestyle change and statin treatment. Measurement of hs-CRP should be done in patients free of infection or acute illness. This kit is intended to use in quantitative detection of CRP content in human serum, plasma or whole blood.