CDIA™ Human Adenovirus Test Cassette - Creative Diagnostics

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CDIATM Human Adenovirus Test Cassette (DTS551)

Intended Use

The Adenovirus Test Device is a rapid chromatographic immunoassayfor the qualitative detection of adenovirusin human feces specimen, providing results in 10 minutes. The test utilizes antibody specific for Adenovirus to selectively detect Adenovirus from human feces specimens.
  • Stool
  • Cassette
  • Relative Sensitivity: 99.9%(95.6%- 99.9%)

Product Introduction

General Description
Acute diarrheal disease in young children is a major cause of morbidity worldwide and is a leading cause of mortality in developing countries. Research has shown that enteric adenoviruses,primarily Ad40 and Ad41, are a leading cause of diarrhoea in many of these children, second only to Rotavirus. The viral pathogens have been isolated throughout the world, and can cause diarrhoea in children year round. Infections are most frequently seen in children less than two years of age,but have also been found in patients of all ages.Further studies indicate that adenoviruses are associated with 4-15% of all hospitalized cases of viral gastroenteritis. Rapid and accurate diagnosis of gastroenteritis due to adenovirus is helpful in establishing the etiology of gastroenteritis and related patient management.Other diagnostic techniques such as electron microscopy (EM) and nucleic acid
hybridization are expensive and labor-intensive. With the self-limiting nature of adenovirus infection,such expensive and laborintensive tests may not be necessary.
Principle Of The Test
The Adenovirus Rapid Test(Cassette) is a qualitative, lateral flow immunoassay for the detection of Adenovirus in human feces specimen. In this assay Adenovirus is detected with the aid of specific antibodies against Adenovirus. After the addition of the sample(feces diluted in buffer) a color-labelled antibody specifically binds to the virus if it is presentin the sample. When this complex migrates upward on the membrane by capillary action,it is captured with the aid of another specific antibody at the test result line region of the test. A red test result line is generated. If no virusis present the color labelled antibody can not bind at the test result line region. No red test result line is formed. So the presence of a colored test result line indicates a positive result, while its absence indicates a negative result. To serve as a procedural control,a colored line will always appear in the control line
region indicating that proper volume of specimen has been added and membrane wicking has occurred.

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