D-Dimer is a Fibrin Degradation Products (FDPs), which are formed whenever fibrin is broken down by enzymes. D-dimers are unique in that they are the breakdown products by plasminof a fibrin mesh that has been stabilised by Factor XIII. This factor crosslinks the E-element to two D-elements. This is the final step in the generation of a thrombus. Elevated levels of D-Dimer are an indication of active fibrinolysis and have been shown in patients with disseminated intravascular coagulation (DIC), deep vein thrombosis (DVT), pulmonary emblolism.
Principle Of The Test
Elevated concentrations of D-dimer indicated increased coagulatory and fibrinolytic activity.a