CDIA™ Legionella Pneumophila Antigen Test Cassette - Creative Diagnostics

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CDIATM Legionella Pneumophila Antigen Test Cassette (DTS348)

* For research use only, not for use in diagnostic procedures.

Intended Use

Legionella Urinary Antigen Rapid Test (Cassette) is an in vitro qualitative immunochromatographic assay for the rapid detection of legionella pneumophilia antigens in human urine specimen. The test results are intended to aid in the diagnosis of legionella pneumophila infection and to monitor the effectiveness of therapeutic treatment.
  • Urine
  • Cassette
  • Legionella Urinary Antigen Rapid Test (Cassette) can detect Legionella pneumophila ATCC strain 33152 at about 3000CFU/mL.

Product Introduction

General Description
Legionella pneumophila serogroup I is gram-negative bacillus.It is now recognized to be the common cause of communityacquired and nosocomial pneumonia. Infections caused by this bacterium include the pulmonary disease of pneumonia.The infections may spread through the blood circulation or the lymph system to heart,brain,kidney,liver and spleen.In addition,gastrointestinal symptoms are prominent in Legionella pneumonia. Legionellaire’s disease can be acquired by the inhalation of aerosols associated with air handing systems, respiratory therapy equipment and whirlpool baths.The elderly are seen as most susceptible to the infection, although children and neonates are also affected.About 5% to 39% of people with legionnaires disease die. Legionella pneumophila serogroup I antigen has been detected in urine during acuate phase of the disease. It presents an opportunity for rapid detection of the bacterium with non-invasive method. Rapid diagnosis and early initiation of appropriate antimicrobial therapy can significantly reduce the mortality associated with Legionella pneumonia. L. pneumophila is a facultative intracellular parasitic bacteria that normally invade and replicate inside amoebae and, incidentally, are able to infect human alveolar macrophages.Macrophages are amoeba-like cells that attack potential respiratory pathogens and engulf them.Once inside L. pneumophila parasitize them in a manner very similar to that in its natural hosts.Amoeba that thrive in natural as well as man-made fresh water reservoirs harbor and maintain infective forms of L. pneumophila in nature not only by providing nutrients for their replicaton but also shielding them from environmental stresses such as chlorination. The internalization of the bacteria can be enhanced by the presence of antibody and complement but is not absolutely required. A pseudopod coils around the bacterium in this unique form of phagocytosis. Once internalized, the bacteria surround themselves in a membrane-bound vacuole that does not fuse with lysosomes that would otherwise degrade the bacteria. In this protected compartment the bacteria multiply.

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