Pregnancy-associated plasma protein A (PAPP-A)
Rapid CDIATM PAPP-A kits are intended for the detection of PAPP-A in blood.
Pregnancy-associated plasma protein A (also known as Pappalysin-1) is a protein that in humans is encoded by the PAPPA gene. Pappalysin-1 is used in screening tests for Down syndrome.
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome. Low levels may alternatively predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death.