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The FOB+Tf ( transferrin ) Rapid test is a rapid chromatographic immunoassay (non-invasive assay) for the qualitative detection of human haemoglobin (hHb) and human transferrin (hTf) in human feces specimens which might be useful for the diagnosis of bleeding gastrointestinal disorders.
Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. Human transferrin is encoded by the TF gene. Colorectal cancer occurs in the colon or rectum, and affects both men and women of all racial and ethnic groups. Fecal occult blood should be an important indicator in the diagnostic evaluation of patients with suspected gastrointestinal bleeding of any etiology, not just as an indication of colorectal cancer. The presence of human haemoglobin in feces is inadequate as a screening test for stomach cancer (upper gastrointestinal disorders), because of human haemoglobin derived from the upper digestive tract is broken down in the intestinal tract (the antigenicity is lost). Detection of fecal transferrin, which is more stable in stool than haemoglobin, provides an alternative way of diagnosing the disease in the upper digestive tract.