Allergy, also known as allergic diseases, are IgE-mediated smooth rapid muscle responses that occur in genetically susceptible individuals upon reexposure to certain environmental antigens (allergen). These diseases include food allergies, allergic dermatitis, allergic asthma, and anaphylactic shock. Symptoms may include runny nose, itchy eyes, and scratchy throat, and sneezing. Common allergens include pollen, peanuts, eggs, metals, mold, grass, cat dander,insect stings, medications and so on.
Immunoglobin E (IgE) plays a vital role in allergic diseases. The underlying mechanism of IgE-mediated allergy is that: the allergen (second exposure) binds to the pre-existing IgE (produced in the first exposure) cross-linked with the Fc receptors on the surface of mast cells and basophils, resulting in degranulation and the secretion of inflammatory substances such as histamine, leukotriene (LTC4 and LTD4), and prostaglandin.
Combined with a person’s medical history, a positive result for the specific IgE in a skin or blood test, is the proven test for allergy detection.
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|• IgE (Serum/Plasma)|